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Xu Kang Biology Solemnly Declares to the World: Chinese Medicine Can Prevent and Cure African Swine Fever 100%

来源:成都市蓄康生物科技有限公司  点击数:1017

蓄康生物郑重向世界宣布:中医药100%能防治非洲猪瘟

Xu Kang Biology Solemnly Declares to the World: Chinese Medicine Can Prevent and Cure African Swine Fever 100%

周友 编撰

Zhou You  Compiled

朋友,你见过血泪吗?也许你只在文学作品中见到过这样的词“血泪史”、“血泪帐”、“血泪控诉”.....,不过,我要告诉你,发生非洲猪瘟的猪就在流“血泪”(见图中眼球与眼睑交界处淡红色液体),这是非洲猪瘟病毒百年来对猪生命的践踏和蹂躏的血证,也是猪对非洲猪瘟病毒顽强抗争的血证。世间生命体都有生存权、发展权,猪是人类最好的朋友之一,我是一名执业兽医师,呵护动物健康,让动物快乐的生活是我的义务和权利,所以,我动用了我力所能尽的力量参与了这场抗击非洲猪瘟的战争,从2018年10月开始,我及其公司暂停了母猪研究项目,全力投入非洲猪瘟及其病毒的理论研究、药物筛选、工艺设计、临床应用等,先后6次配方优化,2019年3月30日,在大家的努力下,第7次优化后的配方及其产品取得了颠覆性的进展,当我在与客户交流的过程中,我明显感到了产品带给他们的欣喜和惊讶。2018年4月,我们全面完善了和稳定了配方,通过近期在河北、河南、陕西、广西、山东、辽宁、黑龙江、福建等省的应用,所有阳性猪场在15天的疗程后全部稳定,恢复了正常生产。

Friend, have you ever seen blood and tears?Perhaps you have only seen such words as "history of blood and tears", "account of blood and tears" and "indictment of blood and tears" in literary works. However, I want to tell you that the pigs that have suffered from African swine fever are shedding "blood and tears" (see the pale red liquid at the junction of eyeball and eyelid in the picture). This is the blood evidence of the trample and ravage of African swine fever virus on pig life for 100 years, and also the blood evidence of the pig’s tenacious struggle against African swine fever virus.All living things in the world have the right to subsistence and development. Pigs are one of the best friends of human beings. I am a licensed veterinarian. It is my duty and right to protect the health of animals and make them happy. Therefore, I used my best efforts to participate in the war against African swine fever. From October 2018 onwards, I and my company suspended the sow research project.I devoted all my efforts to the theoretical research, drug screening, process design and clinical application of African swine fever and its virus. I optimized the formula six times successively. On March 30, 2019, thanks to everyone’s efforts, the formula and its products after the seventh optimization made subversive progress. When I was communicating with customers, I obviously felt the joy and surprise brought by the products.In April 2018, we completely improved and stabilized the formula. Through the recent application in Hebei, Henan, Shaanxi, Guangxi, Shandong, Liaoning, Heilongjiang, Fujian and other provinces, all positive pig farms were stabilized and returned to normal production after 15 days of treatment.

如何让阴性猪场持续稳定、阳性猪场快速转阴、清场猪场能确保复养成功,成都蓄康生物在与非洲猪瘟病毒的战斗中,我们认为消灭传染源、切断传播途径、保护易感动物是控制非洲猪瘟的最有效办法,简言之,生物安全+中药,那具体是怎么操作的呢?简单讲就是333法则

How can the negative pig farm be kept stable, the positive pig farm be quickly turned negative, and the clean pig farm be able to ensure the success of rehabilitation? In the fight against African swine fever virus, Chengdu Xukang Biology believes that eliminating the source of infection, cutting off the transmission route, and protecting susceptible animals are the most effective methods to control African swine fever. In short, biosafety+traditional Chinese medicine, how is it specifically operated?Simply put, 333 rule:

一、抓好3部曲:one, pay special attention to the three steps:

1、发病猪淘汰(消灭传染源);2、生石灰消毒(切断传播途径);3、中医药保健(保护易感动物)。1. elimination of diseased pigs (elimination of infectious sources);2, quick lime disinfection (cut off the route of transmission);3, traditional Chinese medicine health care (protection of susceptible animals).

二、中医药保健分3阶段:Two, Chinese medicine health care is divided into three stages:

第一阶段:1-7天,最显著的变化是发病猪逐渐减少,特别是第5-7天内,到第7天几乎停止发病;The first stage: 1-7 days, the most significant change is that the number of diseased pigs gradually decreases, especially within 5-7 days, the disease almost stops on the 7th day;

第二阶段:8-10天,趋于稳定,偶尔出现个别猪出现症状;The second stage: 8-10 days, tend to be stable, occasionally appear individual pig symptoms;

第三阶段:11-15天,猪场恢复正常生产。The third stage: 11-15 days, the pig farm returned to normal production.

三、准确判断产品使用效果的3天:Three, accurately judge the product use effect of 3 days:

使用药物的第5、6、7天,能观察到发病猪数的显著减少,甚至停止发病。On the 5th, 6th and 7th days after drug use, significant reduction in the number of diseased pigs can be observed, and even the disease can be stopped.

1、坚决、彻底、果断淘汰传染源-病猪、潜伏感染猪(这是方案的最关键的第一步)1. Resolutely, thoroughly and decisively eliminate the infectious source-sick pigs and latent infected pigs (this is the most critical first step of the plan)

1.1、我们为什么要淘汰传染源-病猪、潜伏感染猪?1.1. Why should we eliminate the source of infection-sick pigs and latent infected pigs?
a、我国流行的是强毒株(基因II 型,潜伏期4-6天,死亡率100%),没有疫苗;A, China’s epidemic is a virulent strain (type II gene, incubation period 4-6 days, mortality rate 100%), no vaccine;

b、发病的猪大量排毒,是污染饲料和环境的最大传染源;B the diseased pigs detoxify in large quantities, which is the biggest source of contamination to feed and environment.

c、猪一旦表现出临床症状,病理显示猪已经五脏六腑等已严重损伤;C once the pig shows clinical symptoms, the pathology shows that the pig has already suffered serious damage to its internal organs and organs.

d、猪本身的有限经济价值决定了不能治疗,类似的病势在人也难保性命。D the limited economic value of the pig itself determines that it cannot be treated, and similar diseases will not save human life.

e、病猪本身采食、饮水几乎停止。E, the sick pig itself almost stopped eating and drinking water.

1.2、哪些猪是病猪呢?1.2. Which pigs are sick?

1)、主要临床症状:1), the main clinical symptoms:

无症状突然死亡;Sudden asymptomatic death;

发病率低、病死率高;The incidence rate is low and the mortality rate is high.

高热,体温升高40.5 -42.5℃(随着药物的使用,体温升高不明显了。有的用药后呈现低温。);High fever, body temperature rise 40.5 -42.5 (with the use of drugs, body temperature rise is not obvious.Some showed low temperature after taking drugs.);

耳、四肢、腹背部皮肤发红、发绀、出血点、出血斑、甚至血肿;Red skin, cyanosis, bleeding spots, hemorrhage spots and even hematoma on ears, limbs, abdomen and back;

呕吐,腹泻或便秘,粪便带血;Vomiting, diarrhea or constipation, bloody stool;

虚弱、步态僵直,运动失调,不愿站立等;Weak, stiff gait, dyskinesia, unwilling to stand, etc.

精神沉郁;Mental depression;

怕冷、蜷缩、扎堆。Afraid of cold, curled up, huddled up.

偶见眼、鼻有黏液脓性分泌物(个别有血泪)。Occasionally, mucous purulent secretions (blood and tears in some cases) are found in eyes and nose.

2)、其他临床症状:2), other clinical symptoms:

食欲下降,表现出精神沉郁者则无食欲、饮欲(胃肠呆钝);Loss of appetite, showing depressed spirit, has no appetite or desire to drink (dull stomach and intestine);

呼吸困难,湿咳;Dyspnea, wet cough;

关节疼痛、肿胀;Pain and swelling of joints;

妊娠母猪流产、死胎、弱仔。Abortion, stillbirth and weak offspring of pregnant sows.

3)、剖检变化,最明显的剖检病变是: 3), necropsy changes, the most obvious necropsy lesions are:

脾脏显著肿大,一般情况下是正常脾的3-6 倍,颜色变暗,质地变脆;Spleen is obviously enlarged, usually 3-6 times as much as normal spleen, with dark color and brittle texture.

淋巴结( 特别是胃肠和肾) 增大、水肿以及整个淋巴结出血,形态类似于血块;Enlargement and edema of lymph nodes (especially gastrointestinal tract and kidney) and hemorrhage of the whole lymph node, with a shape similar to blood clots;

肾脏表面瘀点( 斑点状出血);Petechiae on renal surface (spotty hemorrhage);

4)、剖检变化还可能包括:4), necropsy changes may also include:

皮下出血;Subcutaneous hemorrhage;

心包积液和体腔积水、腹水;Pericardial effusion, coelomic effusion and ascites;

心脏表面( 心外膜)、膀胱和肾脏( 皮质和肾盂)的出血点;Bleeding points of heart surface (epicardium), bladder and kidney (cortex and renal pelvis);

肺可能出现充血和瘀点,气管和支气管有泡沫,严重肺泡和间质性肺水肿;Congestion and petechiae may appear in the lung, there is foam in trachea and bronchus, severe pulmonary alveoli and interstitial pulmonary edema;

瘀点、瘀斑( 较大的出血),胃、小肠和大肠中过量的凝血;Petechia, ecchymosis (large hemorrhage), excessive coagulation in stomach, small intestine and large intestine;

肝充血和胆囊出血。Liver congestion and gallbladder hemorrhage.

5)、其它症状5), other symptoms

皮肤发黄、黄染;(出血严重的皮肤苍白)Yellow skin, yellow dye;(severe bleeding, pale skin)

1.3、哪些猪是潜伏期的病猪?1.3. Which pigs are incubation period sick pigs?

1)、神态观察法:从临床反馈来看,处于ASF潜伏期的80斤左右的商品猪有收腹动作、腰腹部肌肉震颤、个别猪在栏内“欢跳”(欢跳属于躁动、腹痛,严重的从一个栏跳到另一个栏。欢跳后神呆,与正常的猪欢蹦不一样,目光无神,听到响声能转头。)、眼睛分泌物多(下眼睑与眼球交界处有血泪)、红眼、食欲不振;随后有的猪离群、猪群松散(没有抢食等现象)、猪沉郁、精神不振、对饲养员反应冷淡等。

哺乳仔猪零星死亡,打针时针孔处流血不止;背部皮肤粗糙、蜕皮,消瘦。1) Expression observation: From clinical feedback, commercial pigs weighing about 80 kg in ASF incubation period have abdominal contraction, muscle tremor in waist and abdomen, and individual pigs "jump joyfully" in the hurdles (jumping joyfully belongs to restlessness and abdominal pain, and jumps from one hurdle to another severely.After the joyous jump, he was stupefied, different from the normal pig’s joyous jump. He had no eyes but could turn his head when he heard the noise.), eye secretions (blood and tears at the junction of lower eyelid and eyeball), red eye and loss of appetite;Then some pigs stray, the herd is loose (there is no phenomenon such as snatching food), the pigs are depressed, depressed and indifferent to the feeders.The suckling piglets died sporadically, bleeding from the pinhole during the injection.The skin on the back is rough, peeling and emaciated.

2)、体温确定法:根据猪场健康猪体温为准线,超过平均温度1.5℃的;(分娩前2小时、产后24小时内体温高的除外)。用红外体温仪检测最好。2) body temperature determination method: according to the body temperature of healthy pigs in the pig farm as the guideline, exceeding the average temperature by 1.5;(except for high body temperature within 2 hours before delivery and 24 hours after delivery).The infrared thermometer is the best.

3)、食欲判断法:特别适合定点、定时、定量饲喂的猪场,放料后20分钟内不能吃完饲料、饲料剩余超过15-30%的。对于母猪,有厌食、瘫痪、无乳、眼角流血、突然吃料很好的,往往3-5天后发病。3) Appetite Determination Method: It is especially suitable for pig farms with fixed-point, fixed-time and fixed-quantity feeding. If the feed cannot be eaten within 20 minutes after feeding, and the remaining feed exceeds 15-30%.For sows, anorexia, paralysis, lack of milk, canthus bleeding, sudden eating is very good, often 3-5 days later onset.

临床证明,针对母猪,利用红外体温仪+食欲,能很好的定点淘汰(拔牙式)病原携带者。Clinical evidence shows that for sows, the use of infrared thermometer+appetite can eliminate (tooth extraction) pathogen carriers at a good fixed point.

4)、试剂检测法:根据我国非洲猪瘟病毒特点,建议预防性检测以唾液为最好,死猪则唾液和血液都可以。自然状态下感染的猪,病毒在唾液中出现要先于血液3-20天,但要注意饲料的污染。4) Reagent test method: According to the characteristics of African swine fever virus in China, it is suggested that saliva is the best preventive test, while saliva and blood can be used for dead pigs.In pigs infected under natural conditions, the presence of the virus in saliva should precede that in blood for 3-20 days, but attention should be paid to feed contamination.

1.4、怎么去淘汰病猪?(快、准、狠)1.4. How to eliminate sick pigs?(Fast, Accurate, Hard)

a、如果猪场各栋猪舍内都有猪发病,建议整个猪场关闭;(商品猪)A, if all piggery piggery houses have pig disease, it is recommended that the whole piggery be closed down;(Commercial Pig)

b、如果某一栋猪舍内,不同栏内的猪都有发病(或者超过50%的栏发病),建议整栋淘汰;(商品猪)B, if in a pig house, pigs in different stalls are infected (or more than 50% of stalls are infected), it is recommended that the whole house be eliminated;(Commercial Pig)

c、如果某一栋猪舍内,只有一栏内的个别猪发病、同栏中还有健康猪,建议整栏猪淘汰(如果猪栏之间只有几根栏杆的,临近几栏猪都淘汰);(商品猪)C, if there are only a few pigs in one column in a pigsty and healthy pigs in the same column, it is recommended to eliminate the whole column of pigs (if there are only a few railings between the pigsty, the pigs in the adjacent columns will be eliminated);(Commercial Pig)

d、商品猪超过160斤,立即卖掉。D, commodity pigs over 160 kg, sell immediately.

e、对于母猪完全可以采取定点淘汰制度(定位栏可以;大栏饲喂的执行商品猪淘汰模式。),通过红外体温仪+食欲变化,发现一头淘汰一头,特别是在体温刚升高时立即淘汰。E, for sows can completely adopt fixed-point elimination system (positioning column can;The elimination mode of commercial pigs for large-scale feeding.), through the infrared thermometer+appetite changes, found that one head eliminated one head, especially when the body temperature just rose immediately eliminated.


1.5、为什么对大栏饲养的猪要以栏为单位进行淘汰?1.5. Why should pigs raised in large pens be eliminated in pens?

= 1 \* GB3 对于商品猪,我们建议最好是整栏、整栋淘汰(商品猪是一栏猪同用一个饲槽和饮水器,特别是饲料极易被病猪的唾液和鼻液污染,这是目前病猪传播病毒的主要方式。如果母猪也是大栏饲养,建议采取同样办法淘汰。很多猪栏之间不是实心墙而是栏杆隔离。有的猪场是两栏共用一个食槽。),便于彻底消毒、减少病毒载毒量。(1) For commercial pigs, we suggest that it is best to eliminate them in whole pens and whole buildings (commercial pigs use the same feeding trough and drinking device for one pen of pigs, especially the feed is easily contaminated by saliva and nasal fluid of sick pigs, which is currently the main way for sick pigs to spread the virus.If sows are also raised in large herds, it is recommended to adopt the same method for elimination.Many pigsty are separated by railings instead of solid walls.Some pig farms share a trough with two stalls.), which is convenient for thorough disinfection and reduces the virus carrying amount.

= 2 \* GB3 感染了非洲猪瘟病毒引起发病的猪,由于腹腔积液,眼观往往与吃饱了的猪没有什么大的区别,尤其是保育猪;另外,很多猪场都采用的是自由采食饲喂,故分离病猪是一件技术性很强的工作,所以建议大栏饲养的猪一旦发病最好整栏淘汰。(2) The eyes of pigs infected with African swine fever virus are not much different from those of full pigs due to peritoneal effusion, especially for conservation pigs.In addition, many pig farms use free feed, so separating sick pigs is a highly technical job, so it is suggested that large-scale pigs should be eliminated in whole if they are sick.

= 3 \* GB3 对于大栏饲养的猪,一旦表现出临床症状,分离病猪后剩余的“健康猪”,如果马上使用我们研发的中医药,仍然会持续用药前的发病率(5%-10%)7天左右,那7天后疑似健康的猪大概还剩70%-48%(X*(1-5%)7=70%X,X*(1-10%)7=48%X),7-10天还会零星淘汰部分猪,所以一个疗程15天,剩余率40%-30%,保育猪会更加的少。故建议,大栏饲养的猪发病,必须整栏淘汰。(3) For pigs raised in large farms, once they show clinical symptoms, the remaining "healthy pigs" after separation of diseased pigs will still have a pre-drug incidence rate (5%-10%) of about 7 days if the traditional Chinese medicine developed by us is used immediately. After 7 days, the suspected healthy pigs will probably have 70%-48%(X*(1-5%)7=70%X, X*(1-10%)7=48%X), and some pigs will be eliminated sporadically in 7-10 days. Therefore, a course of treatment will last for 15 days, with a residual rate of 40%-30%, and the number of pigs to be nursed will be even less.Therefore, it is suggested that pigs raised in large farms must be eliminated in whole farms.

= 4 \* GB3 非洲猪瘟的可怕之处:假设猪场非洲猪瘟的发病率为5%、10%,死亡率为100%,存栏X头,如果不干预,则30天后猪场还有多少猪呢?临床实际比这更严重。④ Terrible thing about African swine fever: Suppose the incidence rate of African swine fever in pig farm is 5%, 10%, the mortality rate is 100%, and there are X pigs in stock. If there is no intervention, how many pigs will remain in pig farm after 30 days?Clinical practice is more serious than this.

X*(1-5%)30=0.21X(剩下20%左右的猪了)X*(1-5%)30=0.21X (about 20% pigs left)

X*(1-10%)30=0.04X(几乎猪就慢慢消失了)X*(1-10%)30=0.04X (almost pigs disappear slowly)

1.6、对淘汰后剩余的“健康猪”的简单分析1.6. Simple analysis of the remaining "healthy pigs" after elimination

在临床,病猪经饲养员简单的淘汰后,剩下的便是“健康猪”,这些健康猪可以简单的分为:Clinically, after sick pigs are simply eliminated by breeders, the rest are "healthy pigs". These healthy pigs can be simply divided into:

= 1 \* GB3 无非洲猪瘟活病毒的猪;治疗期间不发病;(1) pigs without African swine fever virus;No disease occurred during treatment.

= 2 \* GB3 感染了非洲猪瘟病毒,但局限在鼻腔、口腔周围淋巴结、或者淋巴样组织内的猪;治疗期间不发病;(2) pigs infected with African swine fever virus but confined to lymph nodes or lymphoid tissues around nasal cavity and oral cavity;No disease occurred during treatment.

= 3 \* GB3 非洲猪瘟已经在鼻腔、口腔周围淋巴结内完成复制,并逐渐向二级复制器官组织细胞转移的猪,但血液中病毒数量很少,治疗期间可能不发病;(3) pigs in which African swine fever has been replicated in lymph nodes around nasal cavity and oral cavity and gradually transferred to secondary replication organs, tissues and cells, but the number of viruses in blood is very small, and the disease may not occur during treatment;

= 4 \* GB3 在二级复制部位复制,并正在、或者已经形成病毒血症的猪,治疗期间发病;(4 Pigs that replicate at the secondary replication site and are developing or have developed viremia will suffer from the disease during treatment.

所以,使用我们产品后,大概还要持续3-5天的高发病率,这个属于正常现象,不必担心。Therefore, after using our products, the high incidence rate will last for about 3-5 days. This is a normal phenomenon and there is no need to worry about it.

2、分区、隔离、消毒,切断传播途径(这是方案的最关键的第二步)2. Partition, isolation, disinfection and cutting off the transmission route (this is the most critical second step of the plan)

战非洲猪瘟,你的消毒对了吗?现在,许多猪场消毒确实有点过度,而且促进非洲猪瘟爆发!比如:Fighting African Swine Fever, Are You Disinfecting Right?At present, disinfection in many pig farms is indeed a bit excessive and promotes the outbreak of African swine fever.For example:

1)、过氧乙酸等带猪消毒,引起鼻粘膜损伤,有利于非洲猪瘟病毒通过鼻腔感染。(我国非洲猪瘟感染的主要途径鼻腔感染。而且长期高密度消毒,也会引起鼻腔菌群失调。)1), peracetic acid and other disinfection with pigs, causing nasal mucosa damage, is conducive to African swine fever virus infection through the nasal cavity.(The main route of African swine fever infection in China is nasal infection.Moreover, long-term high-density disinfection will also cause nasal flora imbalance.)

2)、夏季高温,加上带猪雾化消毒引起猪舍湿度大,有利于非洲猪瘟病毒繁殖(最近南方高发与高温高湿气候有很大关系)。2) The high temperature in summer and the high humidity in the pigsty caused by atomization disinfection of pigs are conducive to the reproduction of African swine fever virus (the recent high incidence in the south has a great relationship with the high temperature and high humidity climate).

表面上是消毒抗非瘟,实际成了非瘟的帮凶。On the surface, it is disinfection and anti-non-pestilence, and has actually become an accomplice to non-pestilence.

2.1、非洲猪瘟的感染途径:2.1, African swine fever infection route:

非洲猪瘟属于高度接触性传染病,即使猪与猪高度接触,如果病毒没有机会到达伤口、鼻腔、口腔等部位,也不具传染性的。在我国还是机械性传播(人员、机械、物品、老鼠、昆虫等)。African swine fever is a highly contagious disease. Even if pigs are highly contacted with pigs, it is not contagious if the virus has no chance to reach the wound, nasal cavity, oral cavity and other parts.In our country, it is still mechanical transmission (personnel, machinery, articles, mice, insects, etc.).

1)、发病最快的感染途径:伤口,如肌肉注射;(这在一些区域、一些猪场通过正常的疫苗普免时已经出现)1) The fastest route of infection: wound, such as intramuscular injection;(This has already occurred in some areas and some pig farms when normal vaccines have been used for immunization)

2)、临床主要感染的途径:鼻腔粘膜;(这是当前带体消毒要特别注意的,如过氧乙酸对鼻粘膜有腐蚀作用。所有的带猪消毒都不可取,消毒液会影响鼻腔菌群。)2) The main route of clinical infection: nasal mucosa;(this is the current belt disinfection should pay special attention to, such as peracetic acid has corrosive effect on nasal mucosa.All disinfection with pigs is not recommended. Disinfectant will affect nasal flora.)

3)、相对最慢的感染途径:口腔感染。 3) The relatively slowest route of infection: oral infection.

2.2、猪场内主要的传播媒介2.2. Main Media in Pig Farms

1)、饲养员是最大的传播媒介:如配种舍是饲养员与猪接触最多的地方,也是高发区;一定严禁饲养员从一个猪栏到另一个猪栏的频繁活动。1) Breeders are the biggest media: for example, breeding houses are the places where breeders contact most with pigs and are also high incidence areas;It must be strictly prohibited for breeders to move frequently from one pigsty to another.

2)、饲料是发病猪传播病毒的最主要传播媒介;(注意,如果饲料污染了成为最大传播媒介,从流行病学角度讲则具有发病率高、流行面广、整体发病等特点。)2) Feed is the most important transmission medium for the transmission of virus from diseased pigs.(Note that if feed contamination becomes the largest transmission medium, it will have the characteristics of high incidence rate, wide epidemic area and overall morbidity from an epidemiological point of view.)

3)、注射针头是最不确定的传播方式;(尤其是规模化猪场疫苗普免时怎么防止传播病毒)3) Injection needle is the most uncertain mode of transmission.(In particular, how to prevent the spread of virus when vaccines are generally dispensed in large-scale pig farms)

2.3、猪场怎么消毒呢?2.3. How to disinfect pig farms?

猪舍内使用生石灰(一定是生石灰,不是熟石灰。使用后只要生石灰出现结块现象立即更换。)消毒(凡是猪不能接触的地面,如走廊等用生石灰覆盖,这是截断当前饲养员传播的最有效方式),保持猪舍干燥(这是抑制非洲猪瘟病毒生存的最佳办法,生石灰能吸收猪舍内的水汽,降低湿度。当然北方有的地方干燥,可以换成新鲜的熟石灰。),没有必要采用带体消毒(非洲猪瘟属于高度接触性传染病,不是空气传播,带体消毒时许多消毒剂很易破坏鼻腔粘膜,破坏鼻腔菌群稳定。呼吸道鼻腔感染是当前主要感染途径。另外还增加了猪舍内湿度,有利于病毒繁殖等。);猪舍外专人用高压动力喷雾器2次/天等(特别是沟、草丛等,非雨天路面也需要生石灰消毒覆盖。猪场大门和售猪台,是外来人员与猪场人员交流的地方,更要用生石灰覆盖,建议此时猪场人员使用一次性防护服)。Quick lime is used in pig house (it must be quick lime, not hydrated lime.Replace quicklime immediately after use as long as it lumps.) Disinfection (covering floors that pigs cannot touch, such as corridors, etc. with quicklime is the most effective way to cut off the current transmission by breeders) and keeping the pigsty dry (this is the best way to inhibit the survival of African swine fever virus, quicklime can absorb water vapor in the pigsty and reduce humidity.Of course, some places in the north are dry and can be replaced by fresh hydrated lime.), there is no need to use belt disinfection (African swine fever is a highly contagious disease, not airborne. Many disinfectants are easy to destroy nasal mucosa and stability of nasal flora during belt disinfection.Respiratory tract and nasal cavity infection is currently the main route of infection.In addition, the humidity in the pig house is increased, which is beneficial to virus reproduction, etc.);Outside the pigsty, a special person uses a high-pressure power sprayer twice per day (especially for ditches, grass, etc.), and the road surface on non-rainy days also needs quick lime disinfection and covering.The gate of the pig farm and the pig selling platform are places where foreign personnel communicate with the personnel of the pig farm. They should be covered with quicklime. It is recommended that the personnel of the pig farm use disposable protective clothing at this time.

从临床大量数据统计分析发现:猪场内人员是最大的传播媒介;饲料是发病猪传播病原的最大媒介;免疫接种成为未来最大危险生产传播方式(传播最快途径)。Statistics and analysis from a large number of clinical data show that: personnel in pig farms are the largest media of transmission;Feed is the largest vector for transmission of pathogens from diseased pigs.Immunization has become the most dangerous mode of production transmission in the future (the fastest way of transmission).

3、营养、环境、免疫、中药,多管齐下,保护易感动物-健康猪(这是方案的最关键的第三步)3, nutrition, environment, immunity, traditional Chinese medicine, multi-pronged approach to protect susceptible animals-healthy pigs (this is the most critical third step of the program)

1)、提供均衡的营养,特别是抗病营养素,如维生素、氨基酸等等;1) Provide balanced nutrition, especially disease-resistant nutrients such as vitamins, amino acids, etc.

2)、提供舒适的环境,防止过度寒热、过度燥湿;确保空气清新等;2), provide a comfortable environment, prevent excessive cold and heat, excessive dampness;Ensure fresh air, etc.

3)、做好疾病的预防,特别是做好猪场常见主要疾病的免疫工作等;3), do a good job in disease prevention, especially to do a good job in pig farm immunization of common major diseases, etc.;

4)、合理使用中医药4) Rational Use of Traditional Chinese Medicine

使用蓄康生物专门研发的抗非洲猪瘟中药,让阴性猪场持续稳定,让阳性猪场快速转阴,让猪场复产稳定可靠。根据非洲猪瘟的病性,我们建议谨慎选择、使用药物,否则适得其反。比如,中医讲究的是辨证,本来性寒的,你却大剂量解热凉血(板蓝根、黄芩等),自然导致猪冰伏(低温症,这在很多地方出现了);本来猪不气虚的,是气滞,你偏偏大补气(如黄芪、桂枝等),自然猪血管损伤致大出血(是血肿,不是出血斑、点);猪在疾病的演变过程中,病性、病情、病位、病势、病机等都在变化,症候也在变化,这些都要准确把握。祖国地域辽阔,各省气候差异也较大,发病特点也有差别等等。否则都会造成乱用药的危害(本来用药防控非瘟,却用药加速非瘟爆发)。The anti-African swine fever traditional Chinese medicine specially developed by Xukang Biology is used to make negative pig farms stable continuously, make positive pig farms rapidly turn negative, and make pig farms stable and reliable for reproduction.According to the disease nature of African swine fever, we suggest careful selection and use of drugs, otherwise it will backfire.For example, traditional Chinese medicine pays attention to differentiation of symptoms and signs, and is originally cold in nature, but you have large doses of antipyretic and blood cooling (radix isatidis, scutellariae radix, etc.), which naturally leads to pig hypothermia (hypothermia, which occurs in many places);Originally, the pig does not suffer from qi deficiency, but qi stagnation. You must greatly invigorate qi (such as Astragalus membranaceus, cassia twig, etc.), and natural pig vascular injury causes massive hemorrhage (hematoma, not hemorrhage spots and spots);During the evolution of the disease, the disease nature, disease condition, disease location, disease potential and pathogenesis of pigs are all changing, and the symptoms are also changing, which should be accurately grasped.The motherland has a vast territory, and the climate of different provinces is also quite different, and the incidence characteristics are also different, etc.Otherwise, it will cause the harm of indiscriminate use of drugs (the original use of drugs to prevent and control non-pestilence, but the use of drugs to accelerate the outbreak of non-pestilence).

5)、溜溜顺拌料使用:5) Use of mixed LiuLiuShun:

溜溜顺包装规格:2kg/袋 Packing specification: 2kg/ bag

5.1)、阳性猪场用法用量:(注意,我们是按照每头每天用量推荐使用的,临床如果按吨配料时,需要认真转换。(5.1) Usage and dosage of positive pig farms: (Note that we recommend it according to the daily dosage per pig head. In clinical practice, if the dosage is per ton, careful conversion is required.)

①、1-7天:(1), 1-7 days:

1kg溜溜顺是10头大猪(体重>50斤)7天用量(14克溜溜顺/头.天),50斤以下的则减半使用(1kg溜溜顺是20头大猪7天用量,7克溜溜顺/头.天)。The use of 1kg LiuLiuShun is 10 big pigs (weight > 50kg) for 7 days (14g LiuLiuShun /head/day), while the use of less than 50kg is halved (1kg LiuLiuShun /head/day is 20 big pigs for 7 days and 7g LiuLiuShun /head/day).

妊娠母猪:每天采食量不得低于3kg(一定注意,不足时添加麸皮等,针对便秘母猪);1kg溜溜顺是10头母猪7天用量,按照日均采食量3kg计算,1Kg溜溜顺拌料:3kg/天.头*10头*7天=210kg饲料。Pregnant sows: feed intake shall not be less than 3kg per day (be careful, bran and the like shall be added in case of deficiency, aiming at constipation sows);1kg of LiuLiuShun is used by 10 sows for 7 days, calculated on the basis of the daily average feed intake of 3kg, and 1Kg of LiuLiuShun is mixed with 3kg/ day. 10 sows *7 days =210kg of feed.

哺乳母猪:1kg溜溜顺是10头母猪7天用量,按照日均采食量5kg计算,1Kg溜溜顺拌料:5kg/天.头*10头*7天=350kg饲料。Lactating sows: 1Kg of LiuLiuShun is used by 10 sows for 7 days, calculated on the basis of the daily average feed intake of 5kg, and 1kg of LiuLiuShun is mixed with 5kg/ day. The feed for 10 sows *7 days =350kg.

②、8-10天:(2), 8-10 days:

0.7kg溜溜顺是10头大猪(体重>50斤)7天用量(10克溜溜顺/.天),50斤以下的则减半使用。(0.7kg溜溜顺是20头大猪7天用量,5克溜溜顺/.天)。The 0.7kg LiuLiuShun is used by 10 big pigs (weight > 50kg) for 7 days (10g LiuLiuShun /head. day), while the less than 50kg is used by half.(0.7kg LiuLiuShun is used by 20 big pigs for 7 days and 5 g slip/day).

③、11-15天:(3), 11-15 days:

0.5kg溜溜顺是10头大猪(体重>50斤)7天用量(7克溜溜顺/头.天),50斤以下的则减半使用。(0.5kg溜溜顺是20头大猪7天用量,3.5克溜溜顺/头.天)。The 0.5kg LiuLiuShun is used by 10 big pigs (weight > 50kg) for 7 days (7g LiuLiuShun /head. day), while the less than 50kg is used by half.(0.5kg LiuLiuShun is used by 20 big pigs for 7 days and 3.5 g LiuLiuShun /head. day).

④、停药15天后,按照第11-15天的正常用量饲喂1周;之后10天/月,预防使用。如果猪场周围突发,马上预防性使用。(4) 15 days after drug withdrawal, feeding for 1 week according to the normal dosage on the 11th-15th day;After 10 days/month, preventive use.If there is a sudden outbreak around a pig farm, it should be used preventively immediately.

1个疗程,10大猪需要溜溜顺1.7kg10头小猪需要溜溜顺0.85kgFor one course of treatment, 10 big pigs need to LiuLiuShun 1.7kg and 10 little pigs need to LiuLiuShun 0.85kg.

5.2)、非发病场使用。(5.2), non-disease field use.

用法用量:Usage and dosage:

母猪、公猪、50斤以上育肥猪:1kg溜溜顺是20头猪7天用量(7克溜溜顺/头.天),拌料;

50斤以下,1kg溜溜顺是40头猪7天用量(3.5克溜溜顺/头.天),拌料;Sows, boars, and fattening pigs weighing more than 50 kg: 1kg of LiuLiuShun is used by 20 pigs for 7 days (7g LiuLiuShun /head. day), mixed with materials;Under 50kg, 1kg of pig is used for 7 days (3.5g LiuLiuShun /head. day) and mixed with materials.

使用时间:10/Usage time: 10 days/month


5.3)、溜溜顺使用时注意:(5.3) Pay attention to the following when using:

1)不能直接倒入搅拌器内混合(先预混合处理),否则,药物与搅拌器内壁粘合;1) cannot be directly poured into the stirrer for mixing (premixing treatment first), otherwise, the medicine is bonded with the inner wall of the stirrer;

2)、开封后的剩余物必须密封,否则吸潮软化呈糊状。2), after opening the residue must be sealed, or moisture absorption softening into a paste.

3)、严禁与任何药物组合使用。3), it is strictly prohibited to use in combination with any drug.

4)、母猪有便秘的马上改变饲料及其饲喂(见用法用量)。4), sow constipation immediately change the feed and feeding (see usage and dosage).

5)、治疗和恢复期间避风寒、7成饱、停繁殖。5), during the treatment and recovery period, take shelter from the wind and cold, 70% full and stop reproduction.

6)、建议疫区随时保持生石灰覆盖猪场消毒,水沟等液体消毒。6) It is suggested that the epidemic area should keep quick lime covering pig farms for disinfection and liquid disinfection such as ditches at any time.

7)、使用中不得增加添加量,我们的质量是有保障的。7) No additional amount shall be added during use. Our quality is guaranteed.

8)、每天根据猪的采食量一天拌料一次,混合均匀后一定密封保存。8) Mix the materials once a day according to the pig’s feed intake, and seal and store them after mixing evenly.

9)、颗粒饲料,一定要打成粉状,否则颗粒饲料+中药混合均匀后,药与饲料分层,影响效果。9) Granular feed must be pulverized; otherwise, after the granular feed and traditional Chinese medicine are mixed evenly, the medicine and the feed are layered, which affects the effect.

10)、发病场用药期间,最好采用定点、定时、定量饲喂(不要自由采食)。10) During the medication period in the onset field, it is best to adopt fixed-point, regular and quantitative feeding (do not feed freely).

11)、高温环境不能使用:饲料调质和制粒、阳光下暴晒、超过45℃环境等。11), high temperature environment cannot be used: feed conditioning and granulation, sun exposure, over 45 environment, etc.

12)、阳性猪场,根据我们的研究和临床证实,病程在12-15天,所以,阳性转阴需要缓慢进行,不能像风寒感冒那样去治疗,也别希望2-3天就恢复正常。这个必须要有思想准备12) Positive pig farms. According to our research and clinical confirmation, the course of disease is 12-15 days. Therefore, the positive conversion to yin needs to be carried out slowly. It cannot be treated like the cold of wind and cold, and it is not expected to return to normal in 2-3 days.This must be prepared mentally.

4、防控非洲猪瘟的错误做法 4, the wrong way to prevent and control African swine fever

1)、病猪,特别是母猪、大猪,有的人不愿意淘汰;整天打针等。有的猪在皮肤发红阶段打针等似乎有效,但只是短暂的效果,很快死亡,特别是使用解热镇痛类化药的(往往伴随低温)。非洲猪瘟发病初时,往往呈现“感冒”样。在临床,一些家庭农场更是不愿意淘汰病猪,最后所有的猪都感染,一定吸取教训。1), sick pigs, especially sows, big pigs, some people are not willing to eliminate;Injections all day long, etc.Some pigs seem to be effective in giving injections at the stage of skin redness, but the effect is only temporary, and they die quickly, especially those using antipyretic and analgesic drugs (often accompanied by low temperature).At the beginning of the onset of African swine fever, it often appears as a "cold".In clinical practice, some family farms are even more reluctant to eliminate sick pigs. In the end, all pigs are infected and lessons must be learned.

2)、很多猪场,开始普遍添加中药,但发病后症状不典型,如体温39.5-40℃、没有斑疹等,很受迷惑,但解剖时大脾十分显著。2) Traditional Chinese medicine has been widely added to many pig farms, but the symptoms after onset are not typical, such as body temperature 39.5-40, no macula, etc. It is very confusing, but the large spleen is very obvious when dissecting.

这些不科学的做法,都错过了最佳的防控时机,损失自然很大。These unscientific practices have all missed the best time for prevention and control, thus causing great losses.

3)、过分依赖消毒,依靠生物安全措施。必须全方位有序、重点突破。蓄康总结的三部曲:发病猪淘汰+生石灰消毒+中医药保健。(复杂问题简单化)。3), too much reliance on disinfection, rely on biological safety measures.We must make all-round and orderly breakthroughs in key areas.The trilogy summarized by Xu Kang: elimination of diseased pigs+quick lime disinfection+traditional Chinese medicine health care.(Simplification of Complex Problems).

4)、大栏饲养的猪,发病后舍不得以栏为单位进行淘汰,病猪健康猪任然混在一起。4) Pigs raised in large pens are reluctant to be eliminated by pens after the onset of disease. Healthy pigs of sick pigs are still mixed together.

5、猪场疑似猪病简单问询信息5. Simple Inquiry Information on Suspected Pig Diseases in Pig Farms

祖国地域广阔,环境气候差异大,猪体质也差异大,同一病原造成猪病症状不一样,望客户详细填写,以便我们为你量身定制产品。从长期的战非洲猪瘟过程中,我们发现:一法、一方、一药不能对所有区域、所有季节、所有猪场所有猪有效,必须因时、因地、因猪而灵活调整The motherland has a vast territory, great differences in environment and climate, and great differences in pig constitution. The same pathogen causes different symptoms of pig diseases. Please fill in the details so that we can tailor products for you.From the long-term battle against African swine fever, we found that one method, one party and one drug cannot be effective for all pigs in all regions, all seasons and all pig farms, and must be flexibly adjusted according to time, place and pig.

1)、是疑似发病猪场还是健康猪场?1) Is it a suspected pig farm or a healthy pig farm?

2)、什么时候开始的发病?发病前,猪有什么异常反应?2) When did the disease begin?Before the onset of the disease, what abnormal reactions did pigs have?

3)、什么猪先发病?妊娠前期母猪、妊娠后期母猪、哺乳期母猪、空怀母猪、100斤以上大猪、40-100斤猪、保育猪。3) What kind of pig first developed the disease?Sows in the first trimester of pregnancy, sows in the second trimester of pregnancy, lactating sows, empty pregnant sows, large pigs weighing more than 100 kg, pigs weighing 40-100 kg, and nursing pigs.

4)、现在哪些猪发病?一个猪场内有几栋猪舍发病?一栋猪舍内有几栏发病?一栏内有几头猪发病?4) Which pigs are suffering from the disease now?How many pig houses in a pig farm are affected?How many columns in a pigsty are affected?How many pigs are sick in the column?

5)、发病率是多少?5) What is the incidence rate?

6)、病程(发病-死亡时间)多长?6) How long is the course of disease (onset-death time)?

7)、体温是多少?7),What is the body temperature?

8)、皮肤有发红、发紫、出血点、出血斑?8), the skin is red, purple, bleeding spots, bleeding spots?

9)、皮肤有黄染(泛黄)吗? 9) Is the skin yellow (yellow)?

10)鼻腔流鼻涕吗?流鼻血吗?10) Does the nasal cavity have a runny nose?Do you have nosebleeds?

11)、有吐血吗?有呕吐吗?11), vomiting blood?Did you vomit?

12)、眼睛有分泌物增多吗?眼睑发红吗?12), eyes have secretion increased?Is the eyelid red?

13)、便血(黑便)吗?粪便干燥吗?13), hematochezia (black stool)?Is the stool dry?

14)、是不是扎堆昏睡?14), is it a bunch of lethargy?

15)、腹腔、胸腔、心包积液吗?15), abdominal cavity, thoracic cavity, pericardial effusion?

16)、脾脏肿大吗?16), splenomegaly?

17)、肝脏肿大吗?胆囊充盈吗?胆囊壁有出血点吗?17), liver swelling?Is the gallbladder full?Is there any bleeding point on the gallbladder wall?

18)、肾脏有出血点吗?18),Is there any bleeding point in the kidney?

19)、肺水肿吗?气管和支气管内有气泡样液体吗?19), pulmonary edema?Is there bubble-like liquid in trachea and bronchus?

20)、心脏有出血点吗?20),Is there any bleeding point in the heart?

21)、肠系膜淋巴结出血吗?肠道内发黑、有凝血块吗?21), mesenteric lymph node hemorrhage?Is there any blood clots or blackness in the intestinal tract?

22)、胃有出血斑、溃疡吗?22) Are there bleeding spots and ulcers in the stomach?

23)、膀胱有出血点吗?23), bladder bleeding point?

6、使用情况统计表6. Statistics of Usage

时间

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7、中西医结合解读非洲猪瘟

周友   成都蓄康生物

非洲猪瘟 (African Swine Fever, ASF) 是由非洲猪瘟病毒 (African Swine Fever Virus, ASFV) 引起的一类热性、斑疹性、高度接触性猪传染病,ASF是世界动物卫生组织法定报告疾病,我国将其列为一类动物疫病。ASF于1921年首次在肯尼亚被报道,2018年8月1日,在我国沈阳市沈北区确诊首例ASF,目前已有27个省、自治区和直辖市先后确诊发生了ASF。至今,ASF在世界范围内蔓延了近100年,但没有有效的疫苗进行防控,给世界养猪业造成了巨大损失。防控ASF,技术层面我们怎么办?中医瘟疫学为我们提供了丰富的理论和诊治方法、方药、经验,如吴又可撰写《温疫论》得“达原饮”方药、余师愚撰写《疫疹一得》传“清瘟败毒饮”方药;吴鞠通三焦辨证、叶天士四分辨证理论等;1956年蒲辅周中医治乙脑、2003年中西医结合抗非典、2013年中西结合战流感等等。故探讨中西医结合防控ASF实有必要和可行。

1、我国ASFASFV的特点

1.1:辽宁省沈阳市沈北区猪场非洲猪瘟情况

该猪场存栏400头,发病猪场累计死亡47 头,据了解,死亡猪多为100 kg 的大猪。剩余存栏生猪336 头。该起疫情的病死率很高(100%),但发病率较低,发病高峰期死亡10 头左右,平常日均死亡3 头左右。此外,同群未见异常、临床健康的猪,随机采集30 头猪的抗凝血、血清样品的病原学检测结果和血清学检测结果均为阴性,提示该起疫情毒株的群内传播能力或有一定局限性。

对刚病死的2 头猪剖检发现:脾脏极度肿大,严重梗死,质脆易碎,其中一头猪脾肿大至少10 倍,一头猪脾肿大5~7 倍;肺出血、质硬,有间质性肺炎变化;下颌淋巴结、肠系膜淋巴结出血,切面呈大理石样变;胃浆膜面弥漫性出血;肾肿胀明显、色淡,未见出血点;扁桃体见陈旧性出血。

p72 基因片段遗传进化分析显示,该样本病毒属于基因II 型,与目前在俄罗斯和东欧流行的格鲁吉亚毒株(Georgia 2007)同属于一个进化分支。

1.2、连云港连成牧业

存栏4753头,8月15号,2号猪舍生猪开始发热,上午发病3头,下午突然死亡;16号发病10头,死亡8头;17号发病150头,死亡23头;18号发病300头,死亡26头,19号死亡18头,多为心衰致死。共发病615头,死亡88头,发病率13%,死亡率14%。认为属于强毒株。

临床症状,皮肤黄染、点状出血;鼻腔流白色泡沫、或带血;便血;肛门温度41-42℃,猪群打堆,抗生素治疗无效;病猪呼吸困难,侧卧,腹式呼吸;肥猪有的急性突然死亡,死前有划水样神经症状;

病理变化:大脾为正常脾脏的3-6倍以上,呈暗红色或者黑色、质地硬、肠淋巴结出血肿胀如紫葡萄;气管内充满白色泡沫,肺淤血水肿。腹腔积液,胆囊出血。

1.3、黑龙江佳木斯

佳木斯市郊区长青乡范家屯某养殖户共养殖生猪87 头( 其中母猪2 头,育肥猪69 头,仔猪16 头) 。从9 月1 日起,育肥猪陆续发病,至9 月3 日共有29 头发病,6 头死亡; 至9 月4 日累计发病39 头,死亡12 头。其所在的范家屯共有养猪户11 个,共养生猪1 564 头,其他猪场未见异常。

佳木斯市向阳区和平村某养殖户发现自家饲养的生猪有不明原因死亡情况,经调查,该养殖户共养殖生猪203 头( 其中母猪2 头,育肥猪191 头,仔猪10 头) 。9 月3 日发现生猪不明原因死亡,至9 月5 日累计发病26 头,死亡10 头,均为育肥猪。其所在的和平村共有养猪户12 个,共养生猪1 831 头,其他猪未见异常。

临床症状:发病猪体温41~42 ℃,皮肤发红,呼吸困难,不愿运动或少动,同时伴有呕吐,有的猪排血便。

剖检病变:剖检6 头病死猪,3 头病死猪的脾脏显著肿大(大黑脾),呈暗黑褐色,边缘钝圆,触之易碎,切面多汁; 胸腔积液颜色呈黑红色,血液凝固不良; 肺脏出血,切面呈大理石样;肝脏有瘀血、易碎; 肾脏有瘀血斑,有的可见散在出血点; 胃黏膜充血、出血,胃底部可见瘀血斑;肠道严重出血,腹部淋巴结切面多汁,肠系膜淋巴结出血严重 。

从我国流行的这场瘟毒-ASFV来看,ASF呈现发展快、变化速、来势凶、病势重、威胁大等特点,即病势凶猛,传变迅速,损伤脏腑经络、耗损气血津液,机体表现热毒炽盛、亡阳衰竭而死。

2、中西医结合解读ASFASFV

2.1、邪毒逆传,气血两燔

目前,我国流行的主要是ASFV强毒株,病程从几小时-7天不等,有个别猪出现暴死,猪首先表现卫分证(发热、怕冷打堆,是由里证郁结浮越于外所致,假卫分证。),然后病情迅速恶化逆传心包,出现营分证和血分证(高温达40~42℃ 、皮肤发绀、发红、出血点、出血斑,心跳加快,呼吸困难,昏睡,有的便血、鼻血,有的黄染等;解剖见心脏外膜出血、心包积液;肝脾肿大。),死亡率100%。从中医关于瘟疫卫气营血正传和逆传的辩证规律来看,短暂的卫分证,迅速逆传心包,出现气(营)血两燔证型的临床特点,非洲猪瘟表现出明显的发展快、变化速、来势凶、病势重、威胁大等特点。

临床上,在一些地方母猪发病明显,我认为主要是母猪带毒严重,母猪属于多年养殖动物,一直处于繁殖周期中,长期定位栏生活,持续繁殖就是持续应激;蓝耳、圆环等阳性率高,为ASFV进入扁桃体打开了门户;霉菌及其毒素和药物等引起的肝肾损伤(泪斑、眼屎、蛋白尿等);贫血(母猪背脊渗血、体液调节下降);营养和饲喂等造成的便秘、母猪的体质等等,这无论从中医的“同气相求学说”、还是现代医学的免疫-体液调节都能很好的认识。从流行病学角度看,母猪特别是配种前后的母猪与饲养员是处于高度接触的时期,饲养员是猪场内最大的传播媒介。

2.2、邪毒炽盛,迫血妄行

血得寒则凝、得温则通、得热则妄行。热为阳邪,其性酷烈,蟠灼营血,致使血液沸腾,继而妄行不循血府,溢于脉外,正如柳宝治所说:“血为热所迫,不安其络,因而上溢下来”。临床证见:耳、四肢、腹背部皮肤发红、发绀、出血点、出血斑(血肿)、粪便带血。解剖后见,脏腑、肠系膜淋巴结(临床有的猪肠道大量出血时,肠系膜淋巴结似紫葡萄状就少见了。)等出血。

据最新研究显示,ASFV感染毛细血管、动脉、静脉和淋巴结附近的巨噬细胞,引起血管损伤,内皮细胞结构破坏,血管通透性增加,加之凝血因子的变化,导致相应组织、器官出现出血、浆液性渗出、血栓、梗死、DIC等病理变化。如肺血管巨噬细胞病变引起的肺间质水肿、内脏的严重出血、体腔(胸腔、心包、腹腔等)等积液。

2.3、邪毒内炽,伤津耗血

邪毒逆传,邪热入营血,迫血外行,消耗营阴,证见出血、胸腔心包腹腔大量积液,病猪便秘与腹泻交替(热结旁流),血便。迫津外泄,消灼阴液,临床表现尿短少黄;哺乳母猪无乳;心神失养而沉郁嗜睡。

2.4、邪毒熏灼,血络瘀阻

《金匮要略》指出:“热之所过, 血为之凝滞。”《丹溪心法六郁》中也提出“血受温热,久必凝淤。” 《温热经纬》:“热毒壅内,络气阻遇。”气为血帅,气滞则血瘀。叶天士曾谓:“火毒盛而蔽其气,淤其血。”王清任则更进一步指出:“血受热煎熬成块”,说明温热邪毒阻碍气血运行,从而导致脉络淤阻。证见:病猪高热持续,耳朵、皮肤发红、发绀、发紫等,皮肤色泽昏暗(实际是肌肉内出血,所以有的地方反馈病猪皮下出血点、斑少);解剖肝脾肿大。

2.5、邪毒横逆,扰神动风

《素问•灵兰秘典论》:“心者,君主之官。神明出焉。《素问•五脏生成篇》:“诸血者,皆属于心。”《素问•痿论》:“心主身之血脉。”。心藏神与心主血脉,二者密切相关,血是心的物质基础,心血充足,心神得养,则皮毛光彩精神倍。证见:病猪精神沉郁、嗜睡、对周围环境反应低下,甚至消失(临床反馈,发病前,有的商品猪呈兴奋状态,可见此病传变之快)。《灵枢•本神》提到:“肝藏血,血舍魂。”,《素问•痿论》:“肝主身之筋膜。”《素问•六节脏象论》:“肝者……其充在筋。热毒伤津耗血、血络瘀阻,肝血不足,血不养筋。证见:病猪嗜卧、后肢不能站立、不愿运动或少动、走路摇晃等。

2.6、邪毒郁滞,水浊内阻

热毒炽盛,不但动血出血留淤、炼伤阴血津液,而且能影响三焦气化功能,使水谷津液不能正常敷布,反而停积成为有害的“痰饮邪毒”,证见心包、胸腹腔积液;以致阴津不足与痰饮蓄积并存,成湿热交织状,交阻肝胆,证见:皮肤泛黄、呕吐;交阻脾胃,证见:腹泻等。

2.7、邪毒熏灼,侵扰血海

妊娠母猪,因邪热炽盛,熏灼脏腑,迫血妄行,侵扰血海,损伤胎气,冲任失固,致母猪流产等,正如朱丹溪所说:“胎漏多因于血热”。证见:重胎母猪流产、病程短、死亡快。

所以,猪感染ASFV,气血耗损、脏腑经络破坏、气机不畅、正气不存,考虑到猪的经济价值、疾病的危害性,猪场一旦发病、或者检测阳性,猪必须马上淘汰、做好消毒、落实生物安全措施等。从目前临床反馈来看,如果整个猪场母猪商品猪都点发,猪场关闭;整栋猪舍点状散发,整栋淘汰;整栏猪个别点发,整栏淘汰;早发现早淘汰早消毒早隔离,同时结合中医药,能有效阻断非洲猪瘟蔓延。

2.8、猪感染ASFV的潜伏期特点

现代医学研究发现:ASFV能够通过呼吸道(鼻腔)、消化道(扁桃体)以及肌肉等多种途径感染猪只,从口腔感染时首先在扁桃体、下颌淋巴结或其他局部淋巴结中复制,之后病毒随血液或淋巴液扩散,形成病毒血症,并前往其他二级器官复制,在肝脏、肺脏、骨髓、肾脏、肠道中都能检出病毒的存在。ASFV 感染初期的主要靶细胞是存在于组织中的单核细胞/ 巨噬细胞,病毒在其中复制并随之扩散到其他组织器官;随后病毒开始大量感染其他类型的细胞,已确定的细胞种类包括:肝细胞、肝肾毛细血管内皮细胞、扁桃体上皮细胞、纤维母细胞、网状细胞、平滑肌细胞、血管外周细胞、肾小球系膜细胞、巨核细胞、淋巴细胞、嗜中性粒细胞等。自然感染的猪,潜伏期4-19天不等(我国流行强毒株4-6天左右)。

正常情况下,非洲猪瘟病毒随着疾病的发展应该有这样传变过程:传染源-易感动物-潜伏期-前驱期-临诊经过期-终结期(死亡),那临床的情况是怎么样的呢?从传染源--易感动物-潜伏期-前驱期就戛然而止,猪表现出明显的低感染率(5-15%,这是非洲猪瘟病毒的又一特点),而且同栏猪群中也有很多健康的。这就是这个非洲猪瘟病毒的弱点,即属于高度接触性传染病,同时在疑似感染的潜伏期的猪体内,非洲猪瘟传变很慢,也就是说“非洲猪瘟病毒-扁桃体-二级器官复制”传变很慢,甚至是中断。正所谓《黄帝内经》曰,“正气存内,邪不可干”。

尽管在ASFV感染的潜伏期,猪处于“健康”状态,但ASFV已经在猪体内大肆流传,从浅表的扁桃体、鼻粘膜下淋巴组织,到脏腑、脊髓、血液等。从中医角度看,火毒(ASFV)此时已潜伏三焦(上焦、中焦、下焦)、往来表里(卫分、气分、营分、血分),这有力的佐证了杨栗山在对疠气致病的认识,“凡见表证,皆里证郁结,浮越于外也,虽有表证,实无表邪”。这也极大地丰富了瘟疫学的卫气营血辨证思想,强毒株的急性ASF一旦表现出临床症状即呈营血证。

所以,只要我们充分运用好中西医两种医学理论,采取整体与局部、宏观与微观、功能与结构、动态与静态、临床辨证分型与实验室检查等相结合,综合分析、判断病因、区分病机、掌握病理,就一定能做出“辨病与辨证相结合”的科学诊断,组方遣药,降服ASFV,根治ASF。

8、战非洲猪瘟产品-溜溜顺研究思路

从2018年10月份开始组织公司相关专家从事理论设计,先后8次配方优化和临床使用,2019年3月30日最终确立了由4个基础配方组合,根据当地气候、环境、猪场实际,量身定做配方。从4月开始扩大临床使用样本数,验证产品效果的重复性、稳定性等。目前河南、河北、山东、广西、辽宁、陕西等地临床反馈:效果确切,阴性场能稳定,阳性场能恢复、复产后生产正常。




2018-5-22   成都蓄康生物   周友   13980539698



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